Are Stem Cell Treatments Effective Research Paper

Are Stem Cell Treatments Effective - Research Paper Example The embryonic SCs (ESCs) are â€Å"pluripotent† cells which can produce tissues of all embryonic germ layers namely, endoderm, mesoderm and ectoderm. The adult SCs (ASCs) are â€Å"multipotent† cells having the capacity to generate a limited subset of cells (Lodi et al., 2011). of The characteristic ability of the stem cells to renew themselves continuously for long periods and differentiate into specific cell types under appropriate conditions (Zhong, 2008) make them good candidates for cell-based therapies in regenerative or reparative medicine, especially to treat conditions such as diabetes, heart disease, rheumatoid arthritis and several neurodegenerative diseases. Research on and application of ESCs for clinical use is a raging controversy. No regular human ESC therapies are available yet. According to the latest literature on the topic, the only on-going clinical trials employing ESC are being conducted on patients with spinal cord injury (Aznar and Sanchez, 2011 ). However, numerous trials have been/are being conducted with ASCs. ... The human heart muscle damaged by a heart attack does not heal naturally. The primary treatment protocol involves a rapid reperfusion of the infarct related coronary artery in order to curtail the ischemic area and reduce tissue damage (Lodi et al., 2011). Also, angioplasty is required to be conducted soon after, to effectively reestablish the coronary flow. A new strategy of restoring damaged heart tissue is through facilitating repair or regeneration of the tissue. Using ASCs as well as ESCs for heart muscle repair is, currently, an active area of research (stemcells.nih.gov). Autologous skeletal myoblast transplantation undertaken as a major multicenter study for MI treatment did not show any improvement especially with regard to the echocardiographic heart function (Menasche et al., 2008) but improvement in the ejection fraction (EF) was noted (Hagege et al., 2006). Adult human stem cells therapy (AHSCT) could successfully improve EF without causing adverse left ventricular remod eling (Schachinger et al., 2009). Also, in a multicenter double-blind study, intracoronary infusion of HSCs into the infarct artery of 204 patients with acute MI following successful reperfusion therapy was found to significantly reduce MI recurrence restenosis or arrhythmia which are two major adverse post-MI cardiovascular events (Schachinger et al., 2006). Bone marrow-derived mononuclear cells introduced with a catheter into the heart of 21 patients with severe heart failure in a nonrandomized, open-label study appreciably improved myocardial blood flow with associated enhancement of regional and global left ventricular function (Perin et